Taking place entirely during the opening night of a high school's production of Shakespeare's Midsummer Night's Dream, OPENING NIGHT chronicles the on stage disasters and off-stage drama of a group of students, their drama teacher and a visiting B-list TV star.

Six months after the suicide of his fiancé, Patrick, Tommy has hit rock-bottom, avoiding dealing with his emotions through drinking and casual sex. One night he meets John, a man new to LA, in his acting class. Feeling an instant connection with him, he allows John to stay at his place. After time spent together, Tommy develops feelings for John and begins to feel happiness again.

Elle Overton, a college student, becomes obsessed with Katie Kampenfelt, the mysterious heroine of a novel she's just finished reading. When Elle, battling depression, becomes convinced that Katie is actually a flesh-and-blood human being, it sets her on a reckless and terrifying course. An exploration of the potentially dangerous allure of the Internet, the film picks up where its predecessor, the cult hit Ask Me Anything, left off.