Johnny Nine-Toes is a private eye, or hit man; depends on the money and who's paying. Tonight, he's a private eye roaming the back alleys and seedy bars of New Orleans, trying to find a missing girl; caught up in the sex trade. His Journey will take him from the underbelly of the city to the heights of depravity, as he searches for A Dame Called Humidity.

Elizabeth, a lab technician, gets a new confidential job offer to study an unknown patient.