A billionaire celebrity chef seeks revenge on all mankind when a global ban on gluten destroys his life. In the process, Alfredo Manicotti is disfigured into a hideous creature, half-man, half-macaroni, and leads a pasta uprising that threatens all of humanity. It’s up to his spoiled heiress daughter, the angel-haired Emma, to make the ultimate sacrifice and save the world from the impending pastacolypse.

After suffering a heart attack, a world-famous and hard-drinking actor is forced to drive across country with his estranged son—who testified against him in his parents' divorce—on one last madcap adventure.