Continuing the tradition of national artist Ishmael Bernal's benchmark film Working Girls after 25 years, Working Girls of 2010 depicts the role of women in the new millennium. Seven women of different backgrounds, stories and personalities entwined in a colorful story of family, love and life.

George Harrison Apostol (Sarah Geronimo) or better known as DJ Heidee is fast becoming the most popular DJ in town with her segment Heartbreak Hotline. DJ Heidee gives love advice to those who are having trouble with their relationships. Most often than not, she advices her callers to break up with their partners instead of working things out first. One caller (Megan Young) complains about her playboy boyfriend Andrew Escalona (Gerald Anderson). When she breaks up with him on air, Andrew threathens to have DJ Heidee investigated and suspended by the KBP not unless she helps him win back his ex-girlfriend.

As a devoted entrepreneur wins the affections of a free-spirited traveler, he must also win over her stern and disapproving father.

Daniel and Cynthia, a young couple with a child on the way, experience some hard times in Manila. They head back to Baguio, where Daniel is originally from, to start over again. Through the kindness of Alex, Daniel's well-to-do childhood friend, they get to stay in a large house, rent-free; and he gets a job offer as well. Everything seems to be falling into place for them - or so they think - until strange things start to happen in their house.

High school student Jen Guilarman lives in misery with her abusive mother and her mom's lesbian lover. Looking for some escape, she aims to join an all-girl gang which first requires her to undergo a sexual rite. Jen only has one man in mind, and that is her teacher Ariel Basco who has always been sympathetic with her. Suddenly, Jen cries rape and gets her teacher arrested. But behind her tragic fate is a dark truth.

Ombre tells the story of Jake, an aspiring actor who went to Baguio City for a reality star search audition. There, he meets Dennis, a photographer from Manila. Both stay in a transient house owned by Dennis' gay best friend, Brix.

Wade is a spoiled bachelor, who turns his back on sassy girlfriend Maggie when he meets Fe, a hotel intern who looks so much like his ex-girlfriend. Unknown to Wade, Fe’s secret weapon is a love potion, which transforms her into Maggie’s character every time she and Wade meet.

A story about teacher who went to the mountain to teach (NPA).

It is the story of Macky and Molly, a young, poor couple who work as a restaurant manager and an office secretary. Although they have decent jobs in the Philippines, they soon realize that their current routine won't give them a promising future in their home country. So, Molly applies for a student program in Canada.

The story revolves around a hermit named Tokhang. People ridicule her because of her eerie look and scary demeanor. As a bearer of bad tidings, she manages to expose and criticize the foolishness and corruption of the people around her and the society in which they lived in.