An abandoned teen jumps a freight train in Philadelphia intent on reaching his uncle in Indiana, whom he believes will help him with financial difficulties including a pregnant girlfriend. In Ohio, he meets another homeless teen, who escorts him to his uncle. Finding his uncle equally broke, the duo head on to Oklahoma City to try to find the first teen's long-gone ex-con father. A confrontation between father and son send the duo on into exploits in the west including getting beaten up, busting into an Indian reservation church, and hitch-hiking with a beautiful nurse.

Artistic lovers, Viv and Jay, have become trapped in a vicious cycle of codependent heroin addiction. But when Viv’s wealthy parents hire an interventionist to take Viv to rehab, the couple decides to set off on their own with the help of a suboxone prescription... all they have to do is survive a harrowing night through drug withdrawal.