AmeriQua is the story of a lazy recent graduate, Charlie (Bobby Kennedy), whose rich parents cut him off with a $5000 check and an ultimatum to start a life of independence and responsibility. Instead, he buys a plane ticket to Italy, gets robbed upon arrival and winds up in Bologna in the care of his new friend Lele (Lele Gabellone), the self-proclaimed King of Bologna, who lives with a scraggly punkabbestia, Ballo (Gianlucca Bazzoli), and the insatiable prostitute frequenter, Il Pisa (Giuseppe Sanfelice). In Bologna, Lele teaches Chrlie the subtle strategies that the King knows so well, namely hitting on Italian women, throwing all-night parties and inciting general anarchy. Charlie takes to it like a pro and in the process meets the dangerously beautiful Valentina (Alessandra Mastronardi) and all-American Jessica (Eva Amurri).

Maria Silvestri desperately tries to escape a man who is chasing her. The man is faster, he grabs her, drags her to the ground and is on top of her. Then, the darkness. Shortly afterwards two boys discover Maria's body. Leaning over her is a young man with a disturbing appearance: black clothes, disheveled hair, pale, dark-tinted lips. The boy flees but is captured shortly after, his name is Daniel Crawford. He is Maria's American cousin and for some months he had been living with the girl and her father, Bruno Silvestri.

Carlo descends on his former lover's unsuspecting family and the scheming Rocco tries to break up his old rival Marcello's wedding.

FBI agent Malcolm Turner goes back undercover as Big Momma, a slick-talking, slam-dunking Southern granny with attitude to spare! Now this granny must play nanny to three dysfunctional upper-class kids in order to spy on their computer hacker father.

To celebrate their 10th-year high school reunion, a group of twenty-somethings throw an intimate house party to celebrate the event. However, when one of the group accidentally kills another with no explanation. As more brutalities occur, could this be the work of the individuals themselves or possessions by "The Walker"?