Danny, Keys and Zaquersonn are the "Wise Guys", the three brothers of the Cornettos, an "Italian" mafia family. They plan the heist of the millennium only to be thwarted by the rival family, the Gelatos, who were working with someone within the family. The Wise Guys must uncover the mole in the family in order to recover the money that they rightfully stole.

After an encounter with a stranger, Ben's run descends into madness. Ultimately, he begins to question his own sanity and has to face himself.