John and Faith Mills are devout Christians who believe that the prophecies in Revelations are coming true. After a global infectious outbreak, they believe that they are both among the chosen to be saved. When she is bitten by an infected, Faith Mills begins to turn while John helplessly watches. Because of his unyielding views on religion, he will not accept that their faith and devotion will not save her. Gradually, his morality turns to evil in order to keep her body alive.

A ragtag group following the lead of a world-renowned astrologer attempt to thwart an impending invasion by a creature fed up with the mistreatment of their kin.