Casey is a comic fan who left everything in North Carolina to come to New York City to make his dream of becoming a superhero come true after reading "S MAN" Comic Book. Convinced that the comic book predicted his destiny of becoming a superhero as well as saving New York from an imminent threat taking place in the following 24 hours, Casey fight to convince New Yorkers of the danger and to put the pieces of the puzzle together in order save the Big Apple and realizing his dream of becoming a superhero.

Macy and John are nearing the end of their relationship. Mandy and Steve just had a one night stand. Then an infectious outbreak starts turning people into cannibals. Now each of these survivors must deal with their issues as they attempt to survive the outbreak. Low on food, no law enforcement, infected cannibals eating people in the streets, fear grows of what is outside and what might come through the door next.