The pioneering trail to Oregon was littered with constant danger. Yet, the hope of the "promised land" keeps American families westward bound despite overwhelming odds. A calm, clear-thinking pioneer attempts to lead a wagon train through territory occupied by Pawnees and Sioux. Along the way, the hardy settlers face horse thieves, kidnappers, and unpredictable Indian attacks in their push to establish a new life in the rugged West.

The story of Ownie Rodgers, the nephew of crooked Oregon police chief Joe Dandridge. A $70,000 windfall, bequeathed to Dandridge by a man he'd once framed on a bank robbery charge, unleashes innumerable family skeletons. Ownie is obliged to solve the long-ago bank job himself, and in so doing he discovers that his "faithful" girl friend Judy was in on the scheme.

Frank Johnson, a sole witness to a gangland murder, goes into hiding and is trailed by Police Inspector Ferris, on the theory that Frank is trying to escape from possible retaliation. Frank's wife, Eleanor, suspects he is actually running away from their unsuccessful marriage. Aided by a newspaperman, Danny Leggett, Eleanor sets out to locate her husband. The killer is also looking for him, and keeps close tabs on Eleanor.

Three women set out to find eligible millionaires to marry, but find true love in the process.

Rick Belrow Livingston, in love with Broadway star Lisa, is sentenced to 30 days in jail for speeding through a small town. He persuades the judge's daughter Cindy to let him leave for one night, so that he can visit Lisa on her birthday. After that he goes on the town with Cindy and she falls in love with him. But Dr. Schemmer wants his son to become her husband.

A World War I widow loses her only child and spends the rest of her life as a children's nurse.