The plot centers around the Johnson family (consisting of Chris (Rob Hartz) and Ellen (Kathleen Cameron) Johnson, and their son Casey (Hy Rillero)) of Los Angeles, California, one of a small number of families to survive a global pandemic that, according to the opening of the film, occurs "sometime in the future..." The disease began as a particularly virulent flu strain in Southeast Asia. Efforts made to contain the virus in that portion of the world are ineffective as global transportation networks carry infected individuals all around the world. Hospitals become overloaded, and the public works infrastructure begins to shut down. Eventually, the main characters leave L.A., encountering many hardships along the way. They make it to a friendly small town, where life begins again.

A gang war between a gang and the mafia escalates and claims numerous victims on both sides.

Andy Taggert set out for Hollywood to pursue acting, but years later finds himself working in adult films. Disillusioned and trapped, Andy walks off the set and lands himself in a mental hospital. His estranged parents pick him up and take him to their Arizona retirement community where Andy’s troubles seemingly all but disappear until his past unexpectedly comes back to haunt him.