When a small research plane carrying a group of science students and their professor crash-lands in the middle of nowhere, the survivors go to a nearby farmhouse to look for help but soon find themselves besieged by giant mutant spiders.

Local mechanic Jake LaFond's life is suddenly disrupted when mysterious parasites transform the law-abiding citizens of his quaint hometown into hoards of cannibalistic zombies. Isolated from the outside world by an accident on the only road out of town, Jake turns to Alex, his ex-girlfriend, for help. Together they try to solve the mystery behind this rapidly spreading infection. As the town grow