Nathan's one-night stand ends abruptly when his date finds an alarming growth on his body. As it rapidly gets larger, Nathan gets sicker. He looks to alcohol, the Internet, and a needle for help, but to no avail. Drunk and desperate, Nathan finally reaches out to an unlikely source: a former hook-up, a nurse, who can't believe what he sees.

After her fiancé, Rod, and her half-sister, Brandy are both brutally murdered, Champagne (a divorcée and exotic dancer from the wrong side of the tracks) uses “all the right moves” to single-handedly take on the largest sex, drug and back-to-school clothing ring in the country, Mal-Wart.