New Mexico, present day. Brian and Lukas are off to the desert to join a kegger party and to celebrate Lukas’ victory in a motocross competition. His winning prize includes meeting The Deathinator, the biggest action star in the world. The party gets started under the hot desert sun, but Brian isn’t in the mood, so he wanders off and is soon joined by his friend, Lukas. They discover something strange in the desert which leads them into a secret military laboratory, where they discover the disturbing truth of what the government has been doing. Secret experiments on ants and spiders using DNA found in a meteorite which fell to Earth in 1951 has given birth to mutated giant ants which have overrun the facility. Now, it's up to Brian and Lukas to save the world from a giant ant invasion!

The UK Prime Minister and US President have a public rivalry that risks their countries' alliance. But when they become targets of a powerful enemy, they're forced to rely on each other as they go on a wild, multinational run. Allied with Noel, a brilliant MI6 agent, they must find a way to thwart a conspiracy that threatens the free world.