James Bolam portrays serial killer Dr. Harold Shipman in this made-for-TV drama. The film follows the story of Shipman, a general practitioner who throughout his career is believed to have killed as many as 250 of his patients. When the high death rate of his practice was investigated, it was discovered that he had given lethal doses of diamorphine to a vast number of his patients. He was put on trial where he was convicted of 15 murders and sentenced to life imprisonment.

A faithful Jehovah's Witness is forced to shun her own sister because of a religious transgression. As the separation draws out, she starts to question the meaning of God's love.