A UFC Middleweight Championship rematch between current champion Alex Pereira (also former Glory Middleweight and Light Heavyweight Champion) and former champion Israel Adesanya is expected to headline the event. The pairing previously met at UFC 281 in which Pereira captured the title by fifth round knockout. The two also previously met twice in kickboxing matchups. The first in April 2016 which Pereira won by unanimous decision. Their second meeting took place at Glory of Heroes 7 in March 2017 which Pereira won by third round knockout.

UFC on ESPN 51: Luque vs. dos Anjos was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on August 12, 2023, at the UFC Apex facility in Enterprise, Nevada, part of the Las Vegas Metropolitan Area, United States. A welterweight bout between former UFC Lightweight Champion Rafael dos Anjos and Vicente Luque served as the headliner.

LFA 142: Amorim vs. Nichols was a mixed martial arts event that took place on Friday, September 16, 2022 at the Mystic Lake Casino Hotel in Prior Lake, Minnesota.

UFC Fight Night 239: Tuivasa vs. Tybura was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on March 16, 2024, at the UFC Apex facility, in Las Vegas, NV, United States. A heavyweight bout between Tai Tuivasa and Marcin Tybura was scheduled for UFC 298 but the bout was moved in order to headline this event.

UFC Fight Night: Burns vs. Brady was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on September 7, 2024, at the UFC Apex facility in Las Vegas, Nevada, United States. A welterweight bout between former UFC Welterweight Championship challenger Gilbert Burns and Sean Brady served as the main event.

UFC on ESPN 66: Machado Garry vs. Prates was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on April 26, 2025, at the T-Mobile Center in Kansas City, Missouri, United States. A welterweight bout between Ian Machado Garry and Carlos Prates served as the event headliner.

UFC 321: Aspinall vs. Gane was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on October 25, 2025, at the Etihad Arena in Abu Dhabi, United Arab Emirates. A UFC Heavyweight Championship bout between current champion Tom Aspinall and former interim champion Ciryl Gane headlined the event. A UFC Women's Strawweight Championship bout for the vacant title between former Invicta FC Strawweight Champion Virna Jandiroba and Mackenzie Dern took place in the co-main event.

UFC Fight Night 277: Song vs. Figueiredo was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on May 30, 2026, at the Galaxy Arena in Macau SAR, China. A bantamweight bout between Song Yadong and former two-time UFC Flyweight Champion Deiveson Figueiredo headlined the event.