The film follows Zeke (Robert McMurray), Callie (Alicia Marie Marcucci), Les (Seth Gontkovic) and Hunter (Jake Mulliken) on the eve of Hunter's 29th birthday as they share in a few drinks on a seemingly dull day in their hometown of Somerset. The day takes a turn for the worse as everyone they have ever known are suddenly transformed into aggressively murderous flesh eating freaks. The four comrades are forced to hack and slash their way through the reanimated corpses of their closest friends and loved ones, only to find themselves on the precipice of a post apocalyptic wasteland littered with monsters and the looming threat of their fellow survivors.

In need of creative inspiration, a professionally stagnant and hard-partying Los Angeles artist recklessly indulges in a series of drug binges. As the narcotics fly out of control, so does her newfound and inexplicable, yet unquenchable, craving for blood.