Harley Hennage, a gambler, loves Marie but remains silent when he realizes that she is in love with Oliver Corblay, a prospector. After Corblay and Marie marry, Harley moves to the distant town of San Pasqual and does not see his old sweetheart until her husband is killed while staking a claim in the desert.

Michael O'Doone, his wife Margaret and daughter Marge are settlers living in the Northwest. One winter day, while on a journey, Michael meets with an accident and fails to return home. Believing that he is dead, Margaret goes into a state of delirium which enables Buck Tavish, a long-time admirer, to carry her away to his cabin. When she finally comes to her senses she flees in search of Michael, leaving Marge behind.

Velma is unhappily married to Sam Patton, a millionaire roué. Aboard his yacht bound for the South Seas, Sam pays more attention to his guests than to his wife, and she flees when he attempts to force liquor on her. A sudden paralytic stroke renders him helpless, and she believes him dead. A storm comes up, and Velma is washed ashore on a desert isle. She is later joined by Lieut. Paul Mack, whose hydroplane has run out of fuel. They fall in love, but their idyll is broken when they are captured by a band of moonshiners.

Tom Mix plays Tim, a goodhearted cowpuncher who, while riding down a trail, gets robbed of the money he was carrying for the Belgian Babies' Milk Fund.

Daredevil cowboy Ned Ferguson is hired by John Stafford to stop the cattle rustling plaguing his ranch. On the way to the ranch Ned is bitten by a rattlesnake and is nursed by Mary Radford, who is writing a western novel. Ranch foreman Dave Leviatt tells Ned that Mary's brother Ben is behind the rustling. After Ben and Ned come to an understanding, Dave shoots Ben from under cover but Ben is sure that Ned double-crossed him. Mary will have nothing to do with Ned, even after Ned saves her life during a cattle stampede. Ned finally runs down the rustlers, and Mary sees him as a hero instead of merely putting him in her novel.

Kent Hollis has arrived in Dry Bottom, New Mexico to settle the affairs of his dead father. But when he discovers that the town is at the mercy of "Big Bill" Dunlavey and his crew, he decides to stick it out at dad's old ranch for a spell.

Billy Porter sells his ranch and travels to San Francisco to try his hand in the business world. But he's barely off the ferryboat before he gets waylaid by a little newsboy and the boy's pugilist father, "Knockout" McClusky.

Murderous bandits shoot up a town and kill the sheriff. But before he dies, the lawman leaves behind a list of the men responsible for his murder. Twenty-five years later, his son, Buck Marston has grown up and followed in his father's footsteps by becoming a sheriff.

During World War I, German spies were even capable of infiltrating a Tom Mix Western!

Chad Pennington, a movie-cowboy from Hollywood, gets into trouble when he poses as a two-gun outlaw from Texas named Tommy Hawk.