After his daughter Mai is killed in an auto accident, a genius programmer recreates her in the form of a computer program called AI. His jealous brother-in-law, wanting to get his hands on the technology for profit, sends his client to steal it and Mai’s father is killed in the process. Learning of her capture, Mai’s old friends race to free AI from her captors so that she won’t fall into the corporate clutches that threaten to erase her soul.

With the Gyaos re-emerging, Gamera's ties to humanity have been severed with his bond to Asagi broken. Nagamine and Asagi investigate while an orphaned girl named Ayana discovers a new creature she names Iris. Nagamine and Asagi must reach Ayana before she takes her revenge on Gamera, who she blames for the death of her family.

A male corpse is discovered with a smashed face and burned hands. Strangely, the cause of death is determined to be strangulation. When Detective Kaoru Utsumi attempts to corroborate the victim’s ex-wife’s alibi she discovers the mysterious neighbor and only a few small clues to help her disprove a seemingly "airtight" alibi...