Dr. Frankenstein and her assistant, Dr. Yanco, are going to bring one of their experiments to life in Santo Vs. Frankenstein's Daughter. She intends to use a monster named Ursus to do her evil bidding. Using a youth serum to retain their vitality, the doctors set their sights upon none other than El Santo. They need his super human blood to regenerate a stronger youth serum. They kidnap Santo's goddaughter, Norma and lure him into Dr. Frankenstein's lab where he is captured and enslaved. Will Santo make it out alive?

Vic is a struggling auto mechanic with a safe-cracking past and a lot of debt. His girlfriend runs a bar and offers to loan him the money she's saved for remodeling, but Vic is reluctant to take it. When a long-lost cousin from Ireland shows up on his doorstep, the two team up for one last heist.

A young heiress is kidnapped by two aspiring thieves who are then captured by a mad scientist. It's up to the police, Santo, and Blue Demon to rescue them.

The rich landowner La Tigresa suffers several attacks and seeks help from Santo. The attacks continue but Santo protects and she falls for him.

Santo, the saint of the wrestling ring, faces off against an evil voodoo priestess intent on making a more powerful atomic bomb!

Santo goes to Ecuador to sit in nightclubs and watch stage shows, also to crack a counterfeiting ring.

Santo and Mantequilla Nápoles team up to end the curse of La Llorona by getting ahold of a special medallion. Unfortunately, La Llorona escapes in the process.

In the far east the star of great power is stolen by an ambitious woman, who was jealous of the jungle girl who was sent by the gods, also succeeds in kidnapping her. This mission will only be solved by Santo, the masked man of silver who will have to save the girl and recover the star to return the tranquility to the town.

An evil priestess and her twin sister battle for control of a powerful crystal.

Chanoc fights alongside Santo's son against the Killer Vampires.