In 1853 Japan, the story follows the Westernization of Japan, mainly through the story of Kayama, a samurai, and Manjiro, a fisherman. The lives of both men are radically changed by the coming of American ships to Japan.

Penn Jillette and Teller are called upon to display their unique brand of humor to save civilization from strange extraterrestrial beings who have invaded Earth and who, disgruntled and bored with the mundane nature of human life, threaten to blow up the planet unless someone gives them a good reason not to.