The film "Mr. Nobody" is about a young man named Jahongir, whose mother died when he was young. The mother leaves her son in the care of his older brother and leaves him a letter. In this letter, the mother instructs her son to listen to these people, see them as his parents, respect them, and do what they say...

Abbas Khan, who was furious over his sister's untimely death, blames his son-in-law Yusuf for her death and becomes a family scoundrel. Years later, their children Ravshan and Jamila fall in love with each other. Jamila's brother Temur finds out about this and fights Ravshan in order to separate them, in the process Ravshan's friend Mansur is killed and he curses them with his family. Ravshan burns with the fire of revenge, and as a result, Temur dies. In the cruel confrontation of the fates of two loving hearts, the harmony of a relationship full of true love continues. Ravshan and Jamila's love ends tragically due to the confrontation of families and the curse of their family.