The imaginative Bo (9) lives as the only child in a street full of extroverted adults, who think she is quiet. Her parents try to include her in the group, but Bo prefers to fill pages of crafts about the neighbors in her homemade 'humancyclopedia'. When another kid named Rups comes to live in the street for the first time, Bo tries to prove herself by putting her humancyclopedia aside and starting a friendship with her. In this way, she wants to prove to her judgmental neighbors that she is more than just quiet. 'Rups' is a film about the silent power of the introvert and the magic of fantasy.

At the age of nine, Sam starts to realize that she is different from the friends in her class. Over the years, Sam receives many different diagnoses, except for the one thing that makes her different. At the age of twenty, after a childhood with much uncertainty, Sam finally receives the correct diagnosis: autism.