A family is shattered when seven-year-old Jennifer disappears while she and her mother, Sharla, are shopping.

Mary Crow Dog, daughter of a desperately poor Indian family in South Dakota, is swept up in the protests of the 1960s and becomes sensitized to the injustices that society inflicts on her people. She aids the Lakota in their struggle for their rights: a struggle that culminates in an armed standoff with US government forces at the site of an 1890 massacre.

Two Northern Cheyenne men take a road trip from Montana to New Mexico to bail out the sister of one of them who has been framed and arrested in Santa Fe. On the way, they begin to reconnect to their spiritual heritage.