An occult magazine receives e-mails from readers who have experienced mysterious and bizarre events. One particular e-mail interests an editor, Nekonomi, leading her crew to investigate.

In the future, an outbreak of canine flu leads the mayor of a Japanese city to banish all dogs to an island used as a garbage dump. The outcasts must soon embark on an epic journey when a 12-year-old boy arrives on the island to find his beloved pet.