In 2027, in a chaotic world in which humans can no longer procreate, a former activist agrees to help transport a miraculously pregnant woman to a sanctuary at sea, where her child's birth may help scientists save the future of humankind.

Off the coast of the volcanic island of Santorini, the intrepid archaeologist Lara Croft makes the unexpected discovery of a pulsating golden orb able to guide its holder to the mythical Pandora's Box. As the legendary artifact contains ancient mysteries of unfathomable power - said to contain one of the deadliest plagues on Earth, Lara is tasked by MI6 to make sure it doesn't fall into the wrong hands. With the aid of former Marine turned mercenary Terry Sheridan, she travels the world in pursuit of the precious item in a race against time; she must beat the unscrupulous Nobel Prize-winning scientist turned bioterrorist, Jonathan Reiss, to it.