Feeling increasingly trapped, frustrated and alone, middle-aged Los Angeles resident Dee Barnes decides to turn her life (and hopefully the lives of others) around by starting a weekly discussion open to anyone who cares to join. She soon finds her house filled with an assortment of characters, including a bulimic goth, a sexist jerk, and a meek young man who only wants to protect the environment. As they open up to each other with their ideas and feelings, they gradually start to learn more about themselves.

In celebration of their friend Susan’s birthday, a group of women with scandalous, intertwining pasts take off for a weekend retreat in the hills, unaware of the chaos and danger ahead.