An escaped lunatic named Herbie flees a maximum security mental hospital to begin a killing spree through a small town in Arkansas. He disguises himself as a creature and brings his victims to a lab to continue unholy work. The Vatican recruits it's elite team of female freedom fighters to travel to the town where they'll face a demon so powerful that it's very existence can threaten the world.

An undead pope hunts a mysterious creature with apocalyptic power, as two outlaws are pulled into a deadly clash of rival forces and hidden agendas