George Bailey has spent his entire life giving to the people of Bedford Falls. All that prevents rich skinflint Mr. Potter from taking over the entire town is George's modest building and loan company. But on Christmas Eve the business's $8,000 is lost and George's troubles begin.

After experimenting on himself and becoming invisible, scientist Jack Griffin, now aggressive due to the drug's effects, seeks a way to reverse the experiment at any cost.

In sleepy Santa Rosa, restless young Charlie’s world brightens when her sophisticated Uncle Charlie arrives for a long visit. But as his behavior grows increasingly strange, she begins to suspect that her beloved uncle may be hiding a terrible secret—and that danger has quietly entered her home.

Wandered away from his asylum, an amnesiac World War I veteran falls in love with a music hall star but his amnesia makes it difficult to last.

Father O'Malley is sent to St. Mary's, a run-down parochial school on the verge of condemnation. He and Sister Benedict work together in an attempt to save the school, though their differing methods often lead to good-natured disagreements.

In the gay '90s, cardsharps take over a Mississippi riverboat from a kindly captain. Their first act is to change the showboat into a floating gambling house. A ham actor and his bumbling sidekick try to devise a way to help the captain regain ownership of the vessel.

Given a pardon from jail, Roy Earle gets back into the swing of things as he robs a swanky resort.

Middle-class housewife Kay Miniver deals with petty problems. She and her husband Clem watch her Oxford-educated son Vin court Carol Beldon, the charming granddaughter of the local nobility as represented by Lady Beldon. Then the war comes and Vin joins the RAF.

Socialite Judith Traherne lives a lavish but emotionally empty life. Riding horses is one of her few joys, and her stable master is secretly in love with her. Told she has a brain tumor by her doctor, Frederick Steele, Judith becomes distraught. After she decides to have surgery to remove the tumor, Judith realizes she is in love with Dr. Steele, but more troubling medical news may sabotage her new relationship, and her second chance at life.

A group of academics have spent years shut up in a house working on the definitive encyclopedia. When one of them discovers that his entry on slang is hopelessly outdated, he ventures into the wide world to learn about the evolving language. Here he meets Sugarpuss O’Shea, a nightclub singer, who’s on top of all the slang—and, it just so happens, needs a place to stay.