Blondie organizes Housewives of America to perform home-front wartime duties, including guarding the local dam... Blondie for Victory was twelfth in Columbia's series of comedy films based on Chic Young's popular comic strip Blondie. Anxious to do her bit for the war effort, Blondie joins the Housewives of America, a home defense league. Husband Dagwood soon finds that Blondie is neglecting her responsibilities at home in favor of her war work; also disgruntled are Dagwood's chauvinistic boss Mr. Dithers and a newlywed husband whose wife is never home thanks to the defense league.

Dagwood Bumstead must receive a college diploma or lose his job with the Dithers Construction Company. Not wishing to be separated from her husband, Blondie enrolls in college as well. But Leighton College rules stipulate "No Married Couples", forcing Blondie and Dagwood to pretend that they're not married. This causes quite a dilemma when coed Laura Wadsworth begins flirting with Dagwood and Rusty Bryant does the same with Blondie. And Blondie's discovery of a very pleasant secret threatens to expose her and Dagwood's marital status too.

Mr. Dithers invites the Bumsteads on a South American cruise. Somehow Dagwood winds up as the female drummer in the ship's band, while Penny Singleton gets to show off her Broadway background in some lively musical numbers.

Cookie is born, producing unmitigated joy in the Bumstead household. Adding to the chaos a new baby always creates is the appearance of Hans Conried as a cynical author who becomes caught up in the Bumstead lifestyle.

Mr. Dithers leaves Dagwood in charge of the office for a short period. Poor old Dagwood manages to gum things up when he falls for a confidence scam engineered by the duplicitous Toby Clifton. He even finds himself in a compromising position that seriously endangers his future connubial happiness with his wife Blondie. Once again, it's up to Blondie to straighten out the mess.

In a 16th century kingdom in the Netherlands, the newly crowned King Stephan concludes a secret treaty with the Spanish. This puts him at odds with his younger brother, Prince Roland, who favors a treaty with the French. Stephan orders Roland imprisoned but Roland escapes and leads a revolt.

Five individuals from five nations, including the USA, USSR, and China, suddenly find themselves on an alien saucer, where an alien gives each a container holding three capsules. The alien explains that no power on earth can open a given container except a mental command from the person to whom it is given, then anyone may take a capsule and, by speaking a latitude and longitude at it, cause instant death to all within a given radius: thus each of the five has been provided with the power of life and death. Then, they are given 27 days to decide whether to use the capsules, and returned to the places from which each one came...

Blondie and Dagwood are in charge of operations at a mountain motel. The elderly owners of the establishment are in danger of losing their life savings. Among other things, arson threatens.

Baby Dumpling, the six-year-old son of Blondie and Dagwood Bumstead disappears from sight during his first day at school. While Dagwood frantically combs the city in search of the boy, Baby Dumpling spents a nice, safe afternoon with poor little rich girl Melinda Mason, who with her new playmate's help arises from her sickbed to walk across the room for the first time in months.

The Bumstead family is off to see relatives in the country when Blondie runs into Charlie and Millie, an eloping couple needing her help.