Carrie, Mitzie, and Chicago get in trouble a lot in the women's prison, but are offered early parolement if they agree to become subjects of a study on human aggression and antisocial behavior at a Kansas City college. Dr. Blalock, the professor in charge of the study, is accepting money under the table from a shady government contact to use an experimental drug on the women. The drug induces the same hostile behavior the doctor is supposedly trying to cure, and after a while the women have a hard time conducting themselves in a civil manner.

Jefferson City, Missouri: Joseph Randolph, a VIP in a fictional electronics company, has just gotten the sack. The company bigwigs insist it is simply because of downsizing, but Randolph is not buying it. Enraged, he gets a handgun and shoots five managers to death. Then he turns himself in and is eventually put in a psychiatric hospital by the police. His family suffers a series of tragedies that leave only his daughter to wonder about why her father was committed to an institution. She joins with a visiting reporter from Chicago and another interested man, and all three start digging deeper into the company's history.

Former childhood friends Sarah Inman and Ron Johnson have drifted apart in high school. Ron hosts open parties every Friday, but Sarah never attends, preferring to stay home with her homework and dismissing her classmates—especially popular class president Bill Tyler—as shallow. Her aloofness has earned her a reputation as a snob, though she doesn’t realize it. When Ron reluctantly invites her at his mother’s urging, Sarah agrees to go, setting the stage for a clash between her world of isolation and Ron’s world of popularity.