When the pictures from Bergamo in Italy go around the world in spring 2020, even non-medical people know what the word pandemic means. The previously unknown Coronavirus is spreading rapidly across the planet. Four days later, exit and contact restrictions also apply in Germany. Since then, the life of the Konstanz intensive care physician Dr. Carolin Mellau and her family on their heads. The female doctor becomes a member of the crisis team and is on duty around the clock to prepare the clinic for the impending emergency. As an anesthesiologist intubating those infected with COVID-19, she herself carries a high risk of infection. Meanwhile, her husband Stefan has to cancel his concerts as a musician, is no longer allowed to teach his music students and is suddenly sitting at home without an income. Teenage daughter Luzy is not allowed to see her Swiss boyfriend because the border is closed. She and brother Tim cannot go to school. But the worst case for the family is yet to come.

After attending a wedding on a steamboat traveling down the river Spree, three friends from Hamburg become stranded in a newly reunified Berlin. They begin a restless odyssey through the wastelands of a metropolis wavering between an unpredictable future and a lingering past.

Poor but confident and resourceful tailor David trusts, after killing seven flies in one swat, he's a match for any challenge and sets out to prove himself in the wide world. After luck and cunning help him deal with giant Lothar, he arrives at the castle of petty king Ernst, who is ruled by constant migraine and his ambitious, manipulative court counsellor Klaus, who desires to succeed by winning brat princess Paula's hand and claims to be the only saviour who can rid the land of three supernatural dangers.

Georg and Eva have to keep their love secret: Georg is a catholic priest in Bavaria, Germany, obliged to celibacy. They suffer under the situation, but can't stay away from each other.

Shortly after Michael and Inga Lehnert and their kids Tommy and Tilly move into their new home in the countryside, Michael causes an accident in which the 20 years old Jule is seriously injured. Tormented by this Michael spends more and more time at the side of her bed in hospital, where she lies in a coma, neglecting his family and job. When Jule finally wakes up, they fall in love. Although her ex-boyfriend warns her that Michael does not realise that Jule is traumatized by a fear of him and will do anything to bind him to her.