In this frantic urban comedy, a pair of crooks whose ambitions outweigh their good sense steal a million dollars from a New Orleans crime boss, who soon catches up with the thieves and has them killed. However, before they were rubbed out, the robbers hid the loot in an abandoned building. A few years later, the building is torn down to make room for a housing project, and the money is never found. Twenty years later, sometime college student Deion (Andrae Noel) thinks he may have figured out where the money is hidden, but he makes the mistake of sharing his theory with his Uncle Willie (Reynaldo Rey). Soon, Willie has told everyone in the neighborhood about Deion's scheme, and the race is on to see who can find the loot first.

Based on true events, "Lady of Guadalupe" is a moving religious discovery juxtaposing folklore and the present day. Historically significant recreations are used to illustrate the origin of her prevalent and powerful symbolism of Mexican identity and faith. When a young and ambitious reporter (Guillermo Iván) is assigned an article on faith, he finds himself enmeshed in the legend of Juan Diego and Our Lady of Guadalupe. Skeptical of miracles and the importance of modern-day Christianity, the reporter's investigation takes him from cynic to true believer as his personal limits are tested.