Maria Lopez is the daughter of an American mother and a Mexican father, who is the head of a band of insurgents. As a child, she was kidnapped by her father and raised south of the border to hate gringos. She begins to like them a lot better when, during an escape from some Mexican "Rurals," she crosses the border and is captured by Texas Ranger Danny O'Neil. He lets her go, and they fall in love, but their romance is interrupted when she hears that her father has been captured by Americans.

Berenice Arnold spends her time trying to keep her family happy. This is easier said than done -- her brother, Jimmy, is a gambler and he steals 80 dollars that his father was responsible for. Berenice sets out to get the money back, but winds up causing a scandal because of her association with Trix Ulner, a gambler and thief.

Jean, a wealthy young Canadian back from a trip to Europe, meets and falls for Carmen, a pretty young Spanish girl. They marry and have a daughter, but soon afterward Jean discovers his wife is having an affair. She takes her daughter and leaves him, and Jean's luck gets even worse--he loses his business in a fire and his thieving father-in-law steals what little money he has left.

Harold Mark marries Thora after treating her injured grandfather, then migrates to New York City with his young wife to study surgery. While Harold devotes himself to his studies and to social problems, Thora seeks expression with Greenwich Village bohemians and falls prey to the flattery of sculptor Monsieur Duparc, who convinces her that she is neglected by her husband. After the Marks separate, Harold becomes chief surgeon of a state hospital, and Thora spends a year as the guest of Duparc's aunt. On his way to persuade Harold to divorce Thora, Duparc is injured in an automobile accident. Harold unselfishly performs lifesaving surgery on Duparc, while a crazed patient sets fire to the hospital. Afterward, Harold returns to Thora's country home. She follows and they are reconciled.