Hu Ge, a young doctor from Wanfeng Town, is picking medicine in the mountains when he comes across six young girls in distress. That night, the six girls reveal their original forms, which are made of fox demons, and Hu Ge, who abides by the principle that "human beings and demons are different and should not be treated together", is determined to drive away the fox demons

Since the founding of the Yuan Dynasty, Emperor Zhao Yuwen of Yuan Yuan managed martial arts, quelled rebellions inside, and eradicated barbarians outside. The Huntian Supervisory Institute Si Zhengbai and Yitong accompanied Sun Duhu of the Duhufu of Xiyuan, and went to Xiyuan to investigate the locust plague and cholera that plagued the people. Bai Yitong. Bai Yitong observes the heavens, predicts the incision, establishes a calendar to solve problems, and solves strange cases every time, earning the emperor’s trust. But Bai Yitong was strict and inflexible, but the others could not say anything and just listen. Bai Yitong is idle except for his work, and his teacher, Sikong Chong, freely devotes himself to research at the inspectorate. Bai Yitong and Sun Duhu found a hole in a cave during the locust damage investigation, where they are indiscriminately attacked by locusts. Then, Bai Yitong returned to the city with his hands and reported this strange incident to His Majesty the Emper

The film tells the story of the snake demon Liqing who charms all living beings. In order to monopolize Wang Sheng, who fell in love at first sight, she enters Wang Sheng's house by any means, and designs to "swap skins" with Wang Sheng's wife Xu Pan. But Liqing did not expect that her actions repeatedly disobeyed her mother-in-law, who collects men's souls, and her selfishness completely angered her, causing Wang Sheng to be in danger again and again. , Can the love between the two continue?

Based on the novel Poison Genius Consort.