Poker addict Mike McDermott knows the game inside out, but loses his money one night in a game to Russian-American gangster Teddy KGB. Promising his partner Jo he'll give up, he meets up with best friend Lester 'Worm' Murphy, just out of prison and owing lots of money to the wrong kind of people. McDermott becomes his co-guarantor and now there's only one way to raise the money, the pair have to get back into the game.

Bailey and Amanda, a lesbian couple, are determined to have a baby and have created the perfect list of sperm donors, ranked by their ideal characteristics. However, every potential donor they select meets an untimely and bizarre death—falling tree branches, fatal spin classes, art installations gone wrong, and even skydiving accidents. Their "celebrity stretch goal" also meets a gruesome fate. As the deaths mount, Bailey and Amanda begin to wonder if their bad luck is just a coincidence, a curse, or something more sinister at play.