After suddenly being dumped by the live-in girlfriend that he adores, Jude Donnelly hits the road to seek solace from his overwhelming pain. But instead of finding solace, Jude instead experiences three more years of excruciating suffering.

Psychiatrist Sam Foster has a new patient, Henry Letham, who claims to be suicidal. In trying to diagnose him, Sam visits Henry's prior therapist and also finds Henry's mother -- even though Henry has said that he murdered both of his parents. As reality starts to contradict fact, Sam spirals into an unstable mental state. Then he finds a clue as to how and when Henry may try to kill himself, and races to try to stop him.

Miracle at St. Anna chronicles the story of four American soldiers who are members of the all-black 92nd "Buffalo Soldier" Division stationed in Tuscany, Italy during World War II.