Due to a genetic disorder, handsome librarian Henry DeTamble involuntarily zips through time, appearing at various moments in the life of his true love, the beautiful artist Clare Abshire.

When their lesbian sister announces that she's going to have a sex change operation, her southern family has to make some attitude adjustments.

The Grand is in the tradition of improvisational comedies like Best In Show and This Is Spinal Tap. The story is set in the world of professional poker and follows six players who reach the final table of the world’s second most famous high stakes tournament, the Grand Championship of Poker.