Richard Macedo, is a young Mexican-American businessman from Orange County whose life is changed over the course of one night through a series of off beat encounters with the denizens of Mexico City.

A young architect has a double life: he has a beautiful wife and a sexy mistress. His friends advise him to choose one, but this three women gives meaning to his life, including his nosy mother-in-law.

Clotilde dies, and her god-daughter has promised to carry out a final wish for her. Two gangs of thieves and the cops interfere with her fulfilling the promise.

In the city of Latinopolis a man named Sacro is hired by a powerful company to carry out a very dangerous mission with the help of Caos, an angel hunter. Meanwhile in another part of the city Susana and Miguel, two Alter-globalization supporters are looking for their sister Susana, who mysteriously disappeared. In their search they will cross paths with an assorted mix of characters that are lost somehow in this unbelievable but true story of craziness and love.

“Maria, I'm dying!” is a comedy about a hypochondriac man, the only being in the world capable of even terminal colds, and his wife who has to put up with it until he decides to do something about it. The fear of death has never been so fun.