U.S Marshal Mike Donovan has dark memories of the death of his first love. He keeps peace between the Americans and the natives who had temporarily adopted and taken care of him. The evil actions of a white sorcerer lead him to confront the villain in the Sacred Mountains, and, through shamanic rituals conquer his fears and uncover a suppressed memory he would much rather deny.

What happens when indigenous healing rituals and immersive technology converge? Inspired by his own experiences with ayahuasca, a plant infusion traditionally used in healing and self-discovery ceremonies by peoples of the Amazon, director Jan Kounen embarks on a spiritual, visual journey. He attempts to capture the physical and hallucinatory states of such a ceremony on film.

On a quest for emotional healing and spiritual awakening, a naturopathic doctor and an accountant join others in the Peruvian Amazon to drink a psychedelic brew called ayahuasca.

In search of a miracle, an American woman embarks on a journey to the Peruvian Amazon and finds hope in a community, through rituals involving an ancient psychedelic plant known as ayahuasca. With her perception forever altered, she forges a bond with a young indigenous shaman undergoing a crisis of his own, and a motley crew of psychonauts seeking transcendence, companionship, and the meaning of life and death.

James, giving himself 12 months before he has "a license to kill himself," sets off to the Amazon rainforest with hopes of finding a shaman who can save his life.