After paleoclimatologist Jack Hall is largely ignored by UN officials when presenting his environmental concerns about the beginning of a new Ice Age, his research proves true when a superstorm develops, setting off catastrophic natural disasters throughout the world. Trying to get to his son, Sam, who is trapped in New York City with his friend Laura and others, Jack and his crew must travel to get to Sam before it's too late.

Peter Parker is going through a major identity crisis. Burned out from being Spider-Man, he decides to shelve his superhero alter ego, which leaves the city suffering in the wake of carnage left by the evil Doc Ock. In the meantime, Parker still can't act on his feelings for Mary Jane Watson, a girl he's loved since childhood. A certain anger begins to brew in his best friend Harry Osborn as well...

Times are changing for Manny the moody mammoth, Sid the motor mouthed sloth and Diego the crafty saber-toothed tiger. Life heats up for our heroes when they meet some new and none-too-friendly neighbors – the mighty dinosaurs.