Sophie is a twenty-year-old American who has lived her life in isolation, cut off from the world. While on vacation in Palermo with her sister, she meets Giulio and his group of Sicilian friends during her final 24 hours before returning to California. Eager to break free from her sheltered past, Sophie embarks on a whirlwind romance with Giulio.

Sara, Ester, and Miriam are three sisters who have never left the farmhouse where their father and grandmother raised them. They venerate God because they are an extremely Christian family, and fully respect the dogmas and punishments that the Scriptures, and the Old Testament above all, have transmitted to them. They believe in no intermediary, no Church, and no sacred image: Grandma Paolina rises to all those roles that separate them from the Lord’s grace. Adolescence, however, has brought with it questions and physical transformations that have changed the sisters’ outlooks. The doubt that sin has penetrated into their minds and hands is a legitimate one, and each of them responds differently to their first sexual urges. When tragedy strikes the family and their young cousin Primo is forced to come to the farmhouse, the sisters’ lives are forever changed.

A young fashion blogger and an aspiring songwriter seem to have not that much in common, but when Cupid’s arrow hits them, every difference fades away and overnight they decide to get married. Even their fathers do not have anything in common: Gaetano is a strict mayor from Southern Italy, while Diego is a rich entrepreneur from the North. Between the two forthcoming in-laws, instead, is hate at first sight. They seem to agree on one single common goal: prevent this marriage at any cost! After fighting by any means in a struggle that will also involve their two bizarre families, will they manage to say no to the wedding?

A thief and a priest end up magically transported in the year 0's Palestine, where they'll have to make sure that the Nativity will follow its course.