Edward, a young expat gay man, finds himself caged in a glass box, after being abducted by the least person he could ever imagine: his own sister Helen. In order to be freed, he will need to be able to trick Helen, a deeply disturbed yet cunning woman, willing to go to great lengths to cure the young man from his birth nature.

Confronted with his mother's infidelity and his father's emotional absence, João arrives at a sunset where he refuses to return home.

Egas Moniz, a man marked by perseverance and ambition. Audacious and in dissonance with a country full of “narrow-minded” people, Egas Moniz faced everyone so as to impose his scientific ideas, for which he was awarded, at a quite advanced stage of his life, the much-desired Nobel Prize for Medicine in 1949.