A disease carried by common cockroaches is killing Manhattan children. In an effort to stop the epidemic an entomologist, Susan Tyler, creates a mutant breed of insect that secretes a fluid to kill the roaches. This mutant breed was engineered to die after one generation, but three years later Susan finds out that the species has survived and evolved into a large, gruesome monster that can mimic human form.

In a dystopian 2021, Johnny is a data trafficker who has an implant that allows him to securely store data too sensitive for regular computer networks. On one delivery run, he accepts a package that not only exceeds the implant's safety limits—and will kill him if the data is not removed in time—but also contains information far more important and valuable than he had ever imagined. On a race against time, he must avoid the assassins sent to kill him and remove the data before it, too, ends his life.

Hoping to foil his own gold-digging wife's plan, a loathsome businessman arranges his own kidnapping, only to realize that there are plenty of other people interested in his wealth as well.

Cagney and Lacey work a case involving police corruption and document forgery. Chris seeks a prestigious promotion, while Mary Beth has to deal with the return of her sickly, aged father.

Frank Gannon, a veteran cop, is being hunted by his fellow police officers after they learned he has betrayed the brotherhood and exposed to the feds wide scale corruption of the LAPD. He has one day left to prove his case and survive.