After leaving school and failing various work experiences, Pierino decides to go to work as a helper at the bar run by his uncle Nino. He comes across different situations, sometimes involving his friend Pantera, who is able to imitate various sounds, or the girl Marisa, with whom Pierino is madly in love, until he decides to leave for a trip to Austria.

Set in a small town in the Italian countryside, a young and handsome Alfredo returns home after a long time along with his partner Mattia, an African American man. After meeting Alfredo's grandmother, the sweet and crazy Donna Maria, the pair go to see Alfredo's father, Sor Pucci. Alfredo must break the news to his old-fashioned father about his secret. Little did he know his secret will churn into a series of unexpected comic events.

Alvaro Gasperoni, alias Peter returned to Rome with their families from Addis Ababa, where he received his bachelor's degree in medicine. Helped by his father through a recommendation from the P2 Lodge, he manages to get in a hospital in Rome as assistant to the primary. Here begins the struggle with other colleagues to buy up the post of deputy prime. As any good doctor is measured by the number of patients who, the whole family and all his friends are hospitalized; He, in this way, comes from the league winner. The fatal destiny wants its affair is discovered by an inspector of the Ministry of Health, and Peter will be dismissed from the hospital. This will not deter the protagonist by the medical profession; who continue to indulge in a private clinic run "family".

The film covers the last year of Pier Giorgio Frassati life, son of the family that owned the newspaper La Stampa, who lived between 1901 and 1925 and was beatified in 1990.