Tommaso, a young boy growing up in a big family in the country often spies on cousin Marta. Then she marries and moves away. The film then following the courses of both their lives. Tom grows up and goes into military service, Marta is separated from her husband.

Naples, 1959. Pure Mathematics professor Renato Caccioppoli, Bakunin's grandson, is a tortured soul. Recently discharged from the psychiatric hospital, left by his wife, and increasingly disillusioned with academia and the Communist Party, he lives his last days with painful detachment.

Based on the memoirs of author Curzio Malaparte, diplomatic liaison between the Allied and Italian forces after the defeat of the Nazis in Italy, The Skin follows the collapse of Italian society under the US occupation and the desperate measures required for survival.