Notorious Baltimore criminal and underground figure Divine goes up against Connie & Raymond Marble, a sleazy married couple who make a passionate attempt to humiliate her and seize her tabloid-given title as "The Filthiest Person Alive".

Teddy, a young writer, ventures to an isolated desert house to complete his first novel, where he meets and seduces the mysterious caretaker, Leo. Layers of memory and hallucination unfold that intertwine the two men.