Will Keane, a Manhattan restaurateur, is content with his playboy lifestyle until he meets Charlotte Fielding, a free-spirited young woman. Together the pair pursue a passionate affair that forces them both to reevaluate what they want out of life, even as fate threatens to steal away their future.

As they prepare for the end of the world, four different people's lives begin to intersect and find out we might not be as alone as we previously thought.

Someone has infused a large shipment of marijuana with the COVID virus, creating a new, deadly strain: COVID 420. Detective Hedges is on a mission to find the culprit and stop the spread.