In the small town of Woods Creek terror arrived in 1962 in the form of a mysterious drifter. A chain of bizarre events and murder ensued then the drifter left town. Now, 50 years later, he has returned.

Boobs, Blood, and Music numbers! That's right. Skeleton Key is back for its final installment. Join Howard as he ventures through notes and nipples coming up against monsters and zombies again and again. Joined by Nicopernicus, Arbuckle, Guy, Codo, and Mandy, Howard must fix the world of its monster infestation that have escaped the town borders of Nilbog!

A school teacher now possessed by a higher being hunts down her favorite students. Only an unwilling bum named Carter Vash stands in her path of mayhem.