Sam, a seemingly poised and glamorous real estate agent in a small mountain community, is revealed to be an unhinged and troubled alcoholic with a dark secret, when a charismatic man named Peter shows up in town one day. As she tries to keep her life from unravelling, an older co-worker named Brenda is targeted by Peter for information at the behest of his powerful and shadowy boss, Mr. Lock.

Jessie deals with a bad breakup, by purchasing a sheet of acid to share with his friends back home in Missouri. He hopes this will erase the bad memory of his college girlfriend, delivering the heartbreaking news to him, during sex. Departing New Orleans, Jessie detours onto Route 61, seeking a change of routine from the monotony of the Interstate. Unexpectedly, his engine fails at a forgotten trailer park in Cleveland, Mississippi. Fearful he's about to be harmed by bikers, Jessie exchanges hits of L.S.D. for safe passage home. During the ebb and flow of the day, Jessie experiences the extraordinary in the pedestrian, whilst resurrecting the lives of many. Inspired by a true misadventure.